The design, synthesis, and in vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives

Author:

Haroon Muhammad1234,de Barros Dias Mabilly Cox Holanda56789,Santos Aline Caroline da Silva1011912,Pereira Valéria Rêgo Alves1011912,Barros Freitas Luiz Alberto56789,Balbinot Rodolfo Bento13141512ORCID,Kaplum Vanessa13141512,Nakamura Celso Vataru13141512,Alves Luiz Carlos169121711,Brayner Fábio André169121711,Leite Ana Cristina Lima56789,Akhtar Tashfeen1234ORCID

Affiliation:

1. Department of Chemistry

2. Mirpur University of Science and Technology (MUST), Mirpur

3. 10250-Mirpur

4. Pakistan

5. Laboratório de Planejamento em química medicinal

6. Department of Pharmaceutical Sciences

7. Health Sciences Centre

8. Federal University of Pernambuco

9. Recife

10. Aggeu Magalhães Research Center

11. Fundação Oswaldo Cruz

12. Brazil

13. Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos

14. State University of Maringá

15. Paraná

16. Laboratório de Imunopatologia Keizo Asami (LIKA)

17. Instituto Aggeu Magalhães

Abstract

Chagas and leishmaniasis are both neglected tropical diseases, whose inefficient therapies have made them remain the cause for millions of deaths worldwide.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference32 articles.

1. Laboratory of immunomodulation , Department of Protozoology/IOC – FIOCRUZ , The Leishmaniasis , 1997 , accessed on 28 th August 2019, http://www.dbbm.fiocruz.br/tropical/leishman/leishext/html/morfologia.html

2. Pan American Health Organization , Leishmaniasis: Epidemiological Report in the Americas , Pan American Health Organization , Washington , 2019 , http://www.paho.org/leishmaniasis

3. Recent Clinical Trials for the Etiological Treatment of Chronic Chagas Disease: Advances, Challenges and Perspectives

4. Benznidazole-Related Adverse Drug Reactions and Their Relationship to Serum Drug Concentrations in Patients with Chronic Chagas Disease

5. Neglected tropical diseases: progress towards addressing the chronic pandemic

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