A hiPSC-derived lineage-specific vascular smooth muscle cell-on-a-chip identifies aortic heterogeneity across segments-Reference-Cited by-同舟云学术

A hiPSC-derived lineage-specific vascular smooth muscle cell-on-a-chip identifies aortic heterogeneity across segments

Published:2023 Issue:7 Volume:23 Page:1835-1851
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Liu Gang¹²^ORCID,Li Jun¹²,Ming Yang¹²,Xiang Bitao¹²,Zhou Xiaonan¹²,Chen Yabin³,Chen Nan¹²,Abudupataer Mieradilijiang¹²,Zhu Shichao¹²^ORCID,Sun Xiaoning¹²,Sun Yongxin¹²,Lai Hao¹²,Feng Sisi⁴,Wang Chunsheng¹²,Zhu Kai¹²

Affiliation:

1. Department of Cardiac Surgery, Zhongshan Hospital Fudan University, 180 Fenglin Road, Shanghai 200032, China

2. Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital Fudan University, 180 Fenglin Road, Shanghai 200032, China

3. School of Life Science and Technology, Shanghai Tech University, 319 Yueyang Road, Shanghai, 200031, China

4. State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China

Abstract

This study firstly developed a hiPSC-derived lineage-specific SMC-on-a-chip model and identified the segmental aortic heterogeneity. The model can be used for disease modelling, drug testing and personalised treatment.

Funder

Shanghai Municipal Health Commission

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D2LC01158A

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