Convergent synthesis of 2-thioether-substituted (N)-methanocarba-adenosines as purine receptor agonists-Reference-Cited by-同舟云学术

Convergent synthesis of 2-thioether-substituted (N)-methanocarba-adenosines as purine receptor agonists

Published:2021 Issue:44 Volume:11 Page:27369-27380
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Suresh R. Rama¹^ORCID,Poe Russell B.²,Lin Baorui³,Lv Kexin³,Campbell Ryan G.¹,Gao Zhan-Guo¹,Liston Theodore E.²,Toti Kiran S.¹^ORCID,Jacobson Kenneth A.¹^ORCID

Affiliation:

1. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, Bethesda, MD, 20892-0810, USA

2. Astrocyte Pharmaceuticals, Cambridge, MA, 02142, USA

3. WuXi Apptec (Tianjin) Co., Ltd, No. 168 Nanhai Road, TEDA, Tianjin, China

Abstract

Enabling efficient synthesis of rigid methanocarba nucleotides and nucleosides as clinically promising purinergic receptor ligands.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA05096F

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5. (N)-Methanocarba 2,N6-Disubstituted Adenine Nucleosides as Highly Potent and Selective A3 Adenosine Receptor Agonists

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