Synthesis, structure and in vitro antiproliferative effects of alkyne-linked 1,2,4-thiadiazole hybrids including erlotinib- and ferrocene-containing derivatives

Author:

Boulhaoua Mohammed1,Pasinszki Tibor2ORCID,Torvisco Ana3,Oláh-Szabó Rita4,Bősze Szilvia4,Csámpai Antal5ORCID

Affiliation:

1. ELTE Eötvös Loránd University, Institute of Chemistry, Department of Inorganic Chemistry, H-1117 Budapest, Hungary

2. Fiji National University, College of Engineering Science and Technology, Department of Chemistry, P.O.Box 3722, Samabula, Suva, Fiji

3. Graz University of Technology, Institute of Inorganic Chemistry, Stremayrgasse 9/V, 8010 Graz, Austria

4. MTA-ELTE Research Group of Peptide Chemistry, Pázmány P. sétány 1/A, H-1117 Budapest, Hungary

5. ELTE Eötvös Loránd University, Institute of Chemistry, Department of Organic Chemistry, H-1117 Budapest, Hungary

Abstract

Fourteen 1,2,4-thiadiazole derivatives were synthesized and structurally characterized; their in vitro antiproliferative activities were evaluated on four tumorous cell lines (U87, A2058, A431, and HepG2).

Funder

Hungarian Scientific Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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