Digestion-on-a-chip: a continuous-flow modular microsystem recreating enzymatic digestion in the gastrointestinal tract

Author:

de Haan Pim12345ORCID,Ianovska Margaryta A.12345ORCID,Mathwig Klaus12345ORCID,van Lieshout Glenn A. A.675,Triantis Vassilis675,Bouwmeester Hans8951011ORCID,Verpoorte Elisabeth12345ORCID

Affiliation:

1. University of Groningen

2. Groningen Research Institute of Pharmacy

3. Pharmaceutical Analysis

4. 9700 AD Groningen

5. The Netherlands

6. FrieslandCampina

7. Amersfoort

8. RIKILT – Wageningen UR

9. Wageningen

10. Wageningen University

11. Division of Toxicology

Abstract

A three-compartment, miniaturized system to pretreat samples with artificial saliva, gastric juice, duodenal juice and bile for gut-on-a-chip applications.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference38 articles.

1. O. H. Petersen , Human Physiology , Blackwell Publishing , Malden, MA, USA , 5th edn, 2007 , pp. 494–539

2. M. Rowland and T. N.Tozer , Clinical Pharmacokinetics and Pharmacodynamics , Lippincott Williams & Wilkins , Baltimore, MD, USA , 4th edn, 2011 , pp. 183–215

3. H. W. Frijlink , D. J.Touw and H. J.Woerdenbag , Biopharmaceutics, in Practical Pharmaceutics , ed. Y. Bouwman-Boer , V. Fenton-May and P. Le Brun , Springer International Publishing , Cham, Switzerland , 1st edn, 2015 , pp. 323–346

4. Development of an In Vitro Digestion Model for Estimating the Bioaccessibility of Soil Contaminants

5. A Microfluidic System to Evaluate Intestinal Absorption

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