Development of selective agents targeting serotonin 5HT1A receptors with subnanomolar activities based on a coumarin core-Reference-Cited by-同舟云学术

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Development of selective agents targeting serotonin 5HT1A receptors with subnanomolar activities based on a coumarin core

Published:2017 Issue:8 Volume:8 Page:1690-1696
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Ostrowska K.¹²³⁴⁵^ORCID,Grzeszczuk D.¹²³⁴⁵,Głuch-Lutwin M.⁶²⁷⁸⁵,Gryboś A.⁶²⁷⁸⁵,Siwek A.⁶²⁷⁸⁵,Dobrzycki Ł.⁹¹⁰¹¹⁵,Trzaskowski B.¹²¹⁰⁵^ORCID

Affiliation:

1. Department of Organic Chemistry

2. Faculty of Pharmacy

3. Medical University of Warsaw

4. 02 097 Warsaw

5. Poland

6. Department of Pharmacobiology

7. Jagiellonian University Collegium Medicum

8. Kraków

9. Crystallochemistry Laboratory, Faculty of Chemistry

10. University of Warsaw

11. 02 093 Warsaw

12. Centre of New Technologies

Abstract

A screening of 18 compounds identified five coumarin derivatives with subnanomolar activity against the 5HT_1A receptor.

Funder

Warszawski Uniwersytet Medyczny

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00281E

Reference24 articles.

1. Serotonin Receptors

2. Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy

3. [3H]1-[2-(4-Aminophenyl)Ethyl]-4-(3-Trifluoromethylphenyl)Piperazine: A Selective Radioligand for 5-HT1AReceptors in Rat Brain

4. 1-Aryl-4-[(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and Their Analogues: Influence of the Stereochemistry of the Tetrahydronaphthalen-1-yl Nucleus on 5-HT1A Receptor Affinity and Selectivity versus α1 and D2 Receptors. 5

5. Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents

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1. Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands;Medicinal Research Reviews;2024-05-29

2. New Piperazine Derivatives of 6-Acetyl-7-hydroxy-4-methylcoumarin as 5-HT1A Receptor Agents;International Journal of Molecular Sciences;2023-02-01

3. Structural modelling and in silico pharmacology of β-carboline alkaloids as potent 5-HT1A receptor antagonists and reuptake inhibitors;Journal of Biomolecular Structure and Dynamics;2022-07-26

4. Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT1A Serotonin Receptor Antagonists;Pharmaceuticals;2021-02-24

5. Pharmacology profile of F17464, a dopamine D3 receptor preferential antagonist;European Journal of Pharmacology;2021-01

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