An intramolecular tryptophan-condensation approach for peptide stapling-Reference-Cited by-同舟云学术

An intramolecular tryptophan-condensation approach for peptide stapling

Published:2018 Issue:3 Volume:16 Page:389-392
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hui Eunice Y.-L.¹²³⁴^ORCID,Rout Bhimsen⁵⁶⁷⁸^ORCID,Tan Yaw Sing⁹³¹⁰^ORCID,Verma Chandra S.⁹³¹⁰¹¹¹²,Chan Kok-Ping¹²³⁴,Johannes Charles W.¹²³⁴^ORCID

Affiliation:

1. Division of Organic Chemistry

2. Institute of Chemical and Engineering Sciences

3. Agency for Science Technology and Research (A*STAR)

4. Singapore 138665

5. Experimental Dermatology Division

6. Institute of Medical Biology

7. A*STAR

8. Singapore 138648

9. Bioinformatics Institute

10. Singapore 138671

11. Department of Biological Sciences

12. National University of Singapore

Abstract

Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at C2 position of the indole moieties via acid-mediated condensation with an aldehyde.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02667F

Reference22 articles.

1. Double Strain‐Promoted Macrocyclization for the Rapid Selection of Cell‐Active Stapled Peptides

2. Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

3. Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

4. Structure of the Stapled p53 Peptide Bound to Mdm2

5. Clinical Overview of MDM2/X-Targeted Therapies

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