High-throughput force measurement of individual kinesin-1 motors during multi-motor transport-Reference-Cited by-同舟云学术

High-throughput force measurement of individual kinesin-1 motors during multi-motor transport

Published:2022 Issue:34 Volume:14 Page:12463-12475
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Shukla Saurabh¹²^ORCID,Troitskaia Alice³,Swarna Nikhila⁴,Maity Barun Kumar²⁴^ORCID,Tjioe Marco²³⁴,Bookwalter Carol S.⁵,Trybus Kathleen M.⁵,Chemla Yann R.²³⁴,Selvin Paul R.²³⁴^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

2. Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

3. Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

4. Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

5. Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA

Abstract

A high-throughput molecular force sensor that uses single-stranded DNA as a force sensing molecule. It can measure pico-Newton level forces of multiple kinesin motors transporting a microtubule.

Funder

National Science Foundation

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR01701F

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5. Cargo Transport: Two Motors Are Sometimes Better Than One