Bromo- and glycosyl-substituted BODIPYs for application in photodynamic therapy and imaging

Author:

Hohlfeld Benjamin F.12,Steen Dorika2,Wieland Gerhard D.2ORCID,Achazi Katharina1,Kulak Nora13ORCID,Haag Rainer1,Wiehe Arno12ORCID

Affiliation:

1. Institut für Chemie u. Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany

2. Biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany

3. Institut für Chemie, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany

Abstract

Structurally diverse BODIPYs were evaluated for their phototoxic activity against four cancer cell lines in a PDT optimization approach. In particular, glycosylated dibromo-BODIPYs showed a high phototoxic effect, as well as pronounced cellular uptake.

Funder

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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