An engineered biosynthetic–synthetic platform for production of halogenated indolmycin antibiotics-Reference-Cited by-同舟云学术

An engineered biosynthetic–synthetic platform for production of halogenated indolmycin antibiotics

Published:2021 Issue:25 Volume:12 Page:8817-8821
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hoffarth Elesha R.¹²³⁴^ORCID,Kong Sunnie¹²³⁴,He Hai-Yan¹²³⁴,Ryan Katherine S.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. The University of British Columbia

3. Vancouver

4. Canada

Abstract

A semi-synthetic system for producing indolmycin, an antibiotic, was developed and used to make indole-substituted, halogenated derivatives of indolmycin, some with modest bioactivity against methicillin-resistant Staphylococcus aureus.

Funder

Michael Smith Foundation for Health Research

Canadian Institutes of Health Research

Genome British Columbia

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D0SC05843B

Reference37 articles.

1. Antibiotic discovery: history, methods and perspectives

2. Antibiotics: past, present and future

3. The resistance tsunami, antimicrobial stewardship, and the golden age of microbiology

4. Origins and Evolution of Antibiotic Resistance

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