Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands-Reference-Cited by-同舟云学术

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands

Author:

Savino Salvatore¹²³⁴,Gandin Valentina⁵⁶⁷⁴,Hoeschele James D.⁸⁹¹⁰¹¹,Marzano Cristina⁵⁶⁷⁴,Natile Giovanni¹²³⁴,Margiotta Nicola¹²³⁴^ORCID

Affiliation:

1. Dipartimento di Chimica

2. Università degli Studi di Bari Aldo Moro

3. 70125 Bari

4. Italy

5. Dipartimento di Scienze del Farmaco

6. Università di Padova

7. 35131 Padova

8. Department of Chemistry

9. Eastern Michigan University

10. Ypsilanti

11. USA

Abstract

DNA and mitochondria of tumor cells are the targets of Pt(iv) complexes of kiteplatin with biologically active dichloroacetate as axial ligands.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

Reference56 articles.

1. Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug , ed. B. Lippert , Verlag Helvetica Chimica Acta , Zürich , 1999 , p. 563

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