Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure-Reference-Cited by-同舟云学术

Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure

Published:2017 Issue:9 Volume:9 Page:1279-1287
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Groba Sara Reinartz¹²³⁴^ORCID,Guttmann Sarah¹²³⁴^ORCID,Niemietz Christoph¹²³⁴^ORCID,Bernick Friedrich¹²³⁴^ORCID,Sauer Vanessa¹²³⁴,Hachmöller Oliver⁵⁶⁷⁴^ORCID,Karst Uwe⁵⁶⁷⁴^ORCID,Zischka Hans⁸⁹¹⁰⁴¹¹^ORCID,Zibert Andree¹²³⁴^ORCID,Schmidt Hartmut H.¹²³⁴^ORCID

Affiliation:

1. Klinik für Transplantationsmedizin

2. Universitätsklinikum Münster

3. 48149 Münster

4. Germany

5. Institute of Inorganic and Analytical Chemistry

6. University of Münster

7. Münster

8. Institute of Molecular Toxicology and Pharmacology

9. Helmholtz Center Munich

10. Oberschleißheim

11. Institute of Toxicology and Environmental Hygiene

Abstract

MDR1 is implicated in the modulation of hepatocyte copper transport following long-term exposure possibly by direct import or indirectly by reducing toxicity at subcellular localizations, including organelles like mitochondria.

Funder

Medizinische Fakultät, Westfälische Wilhelms-Universität Münster

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MT/C7MT00189D

Reference60 articles.

1. Copper as a key regulator of cell signalling pathways

2. Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo

3. Wilson's disease and other neurological copper disorders