Preparation and evaluation of PCL–PEG–PCL polymeric nanoparticles for doxorubicin delivery against breast cancer

Author:

Zhang Linhua12345ORCID,Chen Zhuo12345,Wang Hai12345,Wu Shengjie12345,Zhao Kongyin6785,Sun Hongfan12345,Kong Deling12345,Wang Chun12345,Leng Xigang12345,Zhu Dunwan12345

Affiliation:

1. Institute of Biomedical Engineering

2. Chinese Academy of Medical Sciences & Peking Union Medical College

3. Tianjin Key Laboratory of Biomedical Materials

4. Tianjin 300192

5. China

6. State Key Laboratory of Hollow Fiber Film Materials and Processes

7. Tianjin Polytechnic University

8. Tianjin 300387

Abstract

DOX-loaded polymeric NPs based on PCL–PEG–PCL triblock copolymers were successfully prepared and showed highly efficient targeting and accumulation in tumor via EPR effect. The prepared NPs would be a promising nanosized DDS for cancer therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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