Preparation and evaluation of PCL–PEG–PCL polymeric nanoparticles for doxorubicin delivery against breast cancer-Reference-Cited by-同舟云学术

Preparation and evaluation of PCL–PEG–PCL polymeric nanoparticles for doxorubicin delivery against breast cancer

Published:2016 Issue:60 Volume:6 Page:54727-54737
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Linhua¹²³⁴⁵^ORCID,Chen Zhuo¹²³⁴⁵,Wang Hai¹²³⁴⁵,Wu Shengjie¹²³⁴⁵,Zhao Kongyin⁶⁷⁸⁵,Sun Hongfan¹²³⁴⁵,Kong Deling¹²³⁴⁵,Wang Chun¹²³⁴⁵,Leng Xigang¹²³⁴⁵,Zhu Dunwan¹²³⁴⁵

Affiliation:

1. Institute of Biomedical Engineering

2. Chinese Academy of Medical Sciences & Peking Union Medical College

3. Tianjin Key Laboratory of Biomedical Materials

4. Tianjin 300192

5. China

6. State Key Laboratory of Hollow Fiber Film Materials and Processes

7. Tianjin Polytechnic University

8. Tianjin 300387

Abstract

DOX-loaded polymeric NPs based on PCL–PEG–PCL triblock copolymers were successfully prepared and showed highly efficient targeting and accumulation in tumor via EPR effect. The prepared NPs would be a promising nanosized DDS for cancer therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA04687H

Reference52 articles.

1. The chemotherapeutic potential of doxorubicin-loaded PEG-b-PLGA nanopolymersomes in mouse breast cancer model

2. Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin

3. Doxorubicin, Cardiac Risk Factors, and Cardiac Toxicity in Elderly Patients With Diffuse B-Cell Non-Hodgkin's Lymphoma

4. Improving anticancer activity and reducing systemic toxicity of doxorubicin by self-assembled polymeric micelles

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