Synthesis, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, and molecular docking studies of a novel compound based on combination of flurbiprofen and isoniazide-Reference-Cited by-同舟云学术

Synthesis, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, and molecular docking studies of a novel compound based on combination of flurbiprofen and isoniazide

Published:2020 Issue:33 Volume:10 Page:19346-19352
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Asghar Amina¹²³⁴⁵,Yousuf Muhammad¹⁶⁷⁸^ORCID,Fareed Ghulam⁹¹⁰¹¹⁵,Nazir Rabia¹⁰⁴⁵,Hassan Abida¹²⁵,Maalik Aneela¹³¹⁴⁵^ORCID,Noor Tayyaba¹⁵¹⁶¹⁷⁵,Iqbal Naseem¹⁸¹⁶¹⁷⁵^ORCID,Rasheed Lubna¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Division of Science and Technology

3. University of Education

4. Lahore

5. Pakistan

6. Ulsan National Institute of Science and Technology (UNIST)

7. Ulsan

8. South Korea

9. Pharmaceutical Research Centre

10. Pakistan Council of Scientific and Industrial Research

11. Karachi

12. Higher Education Commission

13. COMSATS University Islamabad

14. Islamabad 45550

15. School of Chemical and Materials Engineering (SCME)

16. National University of Science and Technology (NUST)

17. Islamabad 44000

18. US Pakistan Centre of Advanced Studies in Energy (USPCAS-E)

Abstract

A novel compound (1) shows ∼2.5 and ∼1.7 times enhanced AChE inhibition activity and BuChE inhibition activity respectively compared to flurbiprofen and standard drug (i.e. physostigmine). It has also been confirmed by comparative AutoDock studies.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA02339F

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