An improved synthesis of poly(amidoamine)s for complexation with self-amplifying RNA and effective transfection-Reference-Cited by-同舟云学术

An improved synthesis of poly(amidoamine)s for complexation with self-amplifying RNA and effective transfection

Published:2020 Issue:36 Volume:11 Page:5861-5869
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Gurnani Pratik¹²³⁴^ORCID,Blakney Anna K.⁵⁶⁷⁸⁹^ORCID,Yeow Jonathan¹⁰¹¹⁴^ORCID,Bouton Clément R.⁵⁶⁷⁸⁹,Shattock Robin J.⁵⁶⁷⁸⁹,Stevens Molly M.¹⁰¹¹⁴^ORCID,Alexander Cameron¹²³⁴^ORCID

Affiliation:

1. Division of Molecular Therapeutics and Formulation

2. School of Pharmacy

3. University of Nottingham

4. UK

5. Department of Infectious Disease

6. Imperial College London

7. School of Medicine

8. St Mary's Hospital

9. London W2 1NY

10. Department of Materials and the Department of Bioengineering at Imperial College London

11. SW7 2AZ London

Abstract

Aza-Michael addition to synthesise poly(amidoamines) was optimised to minimise appearance of bimodal molecular weight distributions caused by a radical-branching side-reaction. This significantly improved cellular delivery of a model self-amplifying RNA vaccine.

Funder

Engineering and Physical Sciences Research Council

Royal Society

European Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/PY/D0PY00912A

Reference36 articles.

1. Non-invasive delivery strategies for biologics