Solid phase synthesis of α-amino squaric acid-containing peptides

Author:

Maeda Kentaro123,Kiniwa Yu-ichi123,Ohfune Yasufumi123,Ishiguro Shinichi456,Suzuki Koichi456,Murata Kazuya789,Matsuda Hideaki789,Shinada Tetsuro123

Affiliation:

1. Graduate School of Science

2. Osaka City University

3. Osaka 558-8585, Japan

4. Office of Research Exchange

5. Iwate University

6. Iwate 020-8550, Japan

7. Faculty of Pharmacy

8. Kinki University

9. Osaka 577-8502, Japan

Abstract

A new method has been developed for the synthesis of 3-(1-aminoalkyl)-4-hydroxycyclobut-3-ene-1,2-dione [(α-amino squaric acid (α-Asq)]-containing peptides using solid phase peptide synthesis according to an Fmoc protecting group strategy.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference26 articles.

1. Handles for Fmoc Solid-Phase Synthesis of Protected Peptides

2. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis, ed. A. B. Hughes, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2011, vol. 4

3. Peptides: Chemistry and Biology, ed. N. Sewald and H.-D. Jakubke, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2nd edn, 2009

4. Phenylthiocarbamate or N-Carbothiophenyl Group Chemistry in Peptide Synthesis and Bioconjugation

5. Synthesis of Carbocyclic and Heterocyclic β-Aminocarboxylic Acids

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