Targeting a cell wall biosynthesis hot spot
Author:
Affiliation:
1. Institute of Pharmaceutical Microbiology
2. University of Bonn
3. Bonn
4. Germany
5. German Centre for Infection Research (DZIF)
Abstract
History points to the bacterial cell wall biosynthetic network as a very effective target for antibiotic intervention, and numerous natural product inhibitors have been discovered.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/NP/C7NP00012J
Reference246 articles.
1. An oldie but a goodie – cell wall biosynthesis as antibiotic target pathway
2. Resistance of Gram-positive bacteria to nisin is not determined by Lipid II levels
3. Targeting bactoprenol-coupled cell envelope precursors
4. The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus
5. Bacterial Cell Wall Synthesis: New Insights from Localization Studies
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