Production of 5α-androstene-3,17-dione from phytosterols by co-expression of 5α-reductase and glucose-6-phosphate dehydrogenase in engineered Mycobacterium neoaurum-Reference-Cited by-同舟云学术

Production of 5α-androstene-3,17-dione from phytosterols by co-expression of 5α-reductase and glucose-6-phosphate dehydrogenase in engineered Mycobacterium neoaurum

Published:2019 Issue:7 Volume:21 Page:1809-1815
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Zhao Yunqiu¹²³⁴⁵,Shen Yanbing¹²³⁴⁵^ORCID,Ma Sai¹²³⁴⁵,Luo Jianmei¹²³⁴⁵,Ouyang Wei¹²³⁴⁵,Zhou Haijie¹²³⁴⁵,Tang Rui¹²³⁴⁵,Wang Min¹²³⁴⁵

Affiliation:

1. Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science and Technology)

2. Ministry of Education

3. Tianjin Key Laboratory of Industrial Microbiology

4. Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control

5. College of Biotechnology

Abstract

5α-Androstene-3,17-dione (5α-AD), an important intermediate in the synthesis of steroid drugs, is mainly synthesized by chemical methods in industry.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin City

Tianjin Science and Technology Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/GC/C8GC03489C

Reference37 articles.

1. Clinical implications of the 5α-androstanedione pathway for castration-resistant prostate cancer

2. 5α-Androstane-3,17-dione in peripheral plasma of men and women

3. A Simple Efficient Process for the Synthesis of 16-Dehydropregnenolone Acetate(16-Dpa)–A Key Steroid Drug Intermediate from Diosgenin

4. An efficient synthesis of 5α-androst-1-ene-3,17-dione

5. Selective hydrogenations promoted by copper catalysts. 1. Chemoselectivity, regioselectivity, and stereoselectivity in the hydrogenation of 3-substituted steroids

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