Exploring structural effects in a new class of NRF2 inhibitors-Reference-Cited by-同舟云学术

Exploring structural effects in a new class of NRF2 inhibitors

Published:2023 Issue:1 Volume:14 Page:74-84
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Hou Zhilin¹^ORCID,Lockwood Lizbeth²,Zhang Di²,Occhiuto Christopher J.²^ORCID,Mo Linqing¹,Aldrich Kelly E.¹,Stoub Hayden E.³,Gallo Kathleen A.³,Liby Karen T.²,Odom Aaron L.¹^ORCID

Affiliation:

1. Department of Chemistry, Michigan State University, 578 S. Shaw Ln., East Lansing, Michigan 48824, USA

2. Department of Pharmacology and Toxicology, Michigan State University, 1355 Bogue St., East Lansing, Michigan 48824, USA

3. Department of Physiology, Michigan State University, 567 Wilson Rd., East Lansing, Michigan 48824, USA

Abstract

SAR on NRF2 inhibitor MSU38225 has led to a compound that inhibits expression of NRF2 target genes, reduces proliferation of lung cancer cells through G2/M arrest, and lowers cell migration.

Funder

National Institutes of Health

National Science Foundation

American Association of University Women

Michigan State University

American Chemical Society, Petroleum Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00211F