Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging-Reference-Cited by-同舟云学术

Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging

Published:2014 Issue:13 Volume:2 Page:1779-1790
ISSN:2050-750X
Container-title:J. Mater. Chem. B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Chevallier P.¹²³⁴⁵,Walter A.⁶⁷⁸,Garofalo A.⁶⁷⁸,Veksler I.¹²³⁴⁵,Lagueux J.¹⁹³,Bégin-Colin S.⁶⁷⁸,Felder-Flesch D.⁶⁷⁸,Fortin M.-A.¹²³⁴⁵

Affiliation:

1. Centre de recherche du Centre hospitalier universitaire de Québec (CR-CHUQ)

2. Axe médecine régénératrice

3. Québec, Canada

4. Centre de recherche sur les matériaux avancés (CERMA)

5. Université Laval

6. Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS)

7. UMR 7504 CNRS-Université de Strasbourg

8. 67034 Strasbourg Cedex 2, France

9. Service d’imagerie animale (SIA)

Abstract

Ultra-small MnO nanoparticles pegylated with bis-phosphonate dendrons are efficient positive MRI contrast agents. They show prolonged vascular signal enhancement, followed by efficient excretion through the hepatobiliairy and urinary pathways. This considerably decreases the potential toxicity of MnO NPs.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2014/TB/C3TB21634A

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