Autoantigenicity of human C1q is associated with increased hydrophobicity due to conformational transitions in the globular heads-Reference-Cited by-同舟云学术

Autoantigenicity of human C1q is associated with increased hydrophobicity due to conformational transitions in the globular heads

Published:2015 Issue:5 Volume:11 Page:1370-1377
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Stoyanova Vishnya¹²³⁴⁵,Bogoeva Vanya⁶⁷⁸⁵,Petrova Lidiya⁶⁷⁸⁵,Tchorbadjieva Magdalena¹²³⁴⁵,Petrova Svetla¹²³⁴⁵,Georgieva Ventsislava¹⁹¹⁰¹¹¹²,Georgiev George¹⁹¹⁰¹¹¹²,Deliyska Boriana¹³¹⁴¹⁵¹⁶⁵,Vasilev Vasil¹³¹⁴¹⁵¹⁶⁵,Tsacheva Ivanka¹²³⁴⁵

Affiliation:

1. Sofia University

2. Faculty of Biology

3. Dept. of Biochemistry

4. 1164 Sofia

5. Bulgaria

6. Institute of Molecular Biology

7. Bulgarian Academy of Sciences

8. Sofia 1113

9. Faculty of Chemistry

10. Laboratory Water-Soluble Polymers

11. Polyelectrolytes and Biopolymers

12. 1164-Sofia

13. Nephrology clinic

14. University Hospital “Queen Giovanna”

15. Medical University

16. 1527 Sofia

Abstract

We analyzed the structural features of C1q that underlie its autoantigenicity by the means of a model system using an amphiphilic polyzwitterion (PZ).

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00021A

Reference31 articles.

1. IgG and IgA antibodies to the collagen-like region of C1q in rheumatoid vasculitis

2. Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles

3. Infections as triggers and complications of systemic lupus erythematosus

4. Anti-C1q antibodies and IgG subclass distribution in sera from Chinese patients with lupus nephritis

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1. Anti-Idiotype scFv Localizes an Autoepitope in the Globular Domain of C1q;International Journal of Molecular Sciences;2021-08-01

2. Anti-C1q Antibodies as Occurring in Systemic Lupus Erythematosus Could Be Induced by an Epstein-Barr Virus-Derived Antigenic Site;Frontiers in Immunology;2019-11-07