Pegylated-polycaprolactone nano-sized drug delivery platforms loaded with biocompatible silver(i) complexes for anticancer therapeutics

Author:

Varna Despoina1,Christodoulou Evi1,Gounari Eleni2,Apostolidou Chrysanthi Pinelopi3,Landrou Georgios4,Papi Rigini1,Koliakos George2,Coutsolelos Athanassios G.4ORCID,Bikiaris Dimitrios N.1ORCID,Angaridis Panagiotis A.1ORCID

Affiliation:

1. Aristotle University of Thessaloniki, Department of Chemistry, University Campus, 54124 Thessaloniki, Greece

2. Biohellenika Biotechnology Company, Leoforos Georgikis Scholis 65, 57001 Thessaloniki, Greece

3. Department of Materials Science and Technology and Institute of Electronic Structure and Laser (I.E.S.L.), Foundation for Research and Technology – Hellas (FO.R.T.H.), University of Crete, Vassilika Vouton, 70013 Heraklion, Greece

4. Department of Chemistry, Voutes Campus, University of Crete, 70013 Heraklion, Greece

Abstract

A pegylated-polycaprolactone nano-sized drug delivery system loaded with cytotoxically active and biocompatible silver(i) complexes was developed and evaluated showing effective and prolonged in vitro cytotoxicity against cancer cells.

Funder

State Scholarships Foundation

Aristotle University of Thessaloniki

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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