Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond-Reference-Cited by-同舟云学术

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Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond

Published:2020 Issue:30 Volume:11 Page:7927-7932
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhao Rui¹²³⁴⁵,Shi Pan¹²³⁴⁵,Chen Junyou⁶⁷⁵⁸,Sun Shuaishuai⁶⁷⁵⁸,Chen Jingnan⁶⁷⁵⁸,Cui Jibin⁶⁷⁵⁸,Wu Fangming⁹¹⁰¹¹⁸,Fang Gemin¹²¹³¹⁴¹⁵⁸^ORCID,Tian Changlin¹²³⁴⁵^ORCID,Shi Jing¹²³⁴⁵,Bierer Donald¹⁶¹⁷¹⁸¹⁹,Liu Lei²²⁰²¹⁸^ORCID,Li Yi-Ming⁶⁷⁵⁸^ORCID

Affiliation:

1. Hefei National Laboratory of Physical Sciences at Microscale

2. Department of Chemistry

3. School of Life Sciences

4. University of Science and Technology of China

5. Hefei

6. School of Food and Biological Engineering

7. Hefei University of Technology

8. China

9. High Magnetic Field Laboratory

10. Chinese Academy of Sciences

11. Hefei 230031

12. School of Life Science

13. Institute of Physical Science and Information Technology

14. Anhui University

15. Hefei 230601

16. Department of Medicinal Chemistry

17. Bayer AG

18. 42096 Wuppertal

19. Germany

20. Tsinghua University

21. Beijing 100084

Abstract

We report the first introduction of an ether linkage as surrogate into the disulfide-rich peptides using ether-containing diaminodiacid.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC02374D

Reference49 articles.

1. Disulfide Bonds and Protein Folding

2. The Current State of Peptide Drug Discovery: Back to the Future?

3. Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics

4. Structure determination of the three disulfide bond isomers of α-conotoxin GI: a model for the role of disulfide bonds in structural stability 1 1Edited by P. E. Wright

5. Cysteine-Rich Mini-Proteins in Human Biology

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