New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation-Reference-Cited by-同舟云学术

New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation

Published:2021 Issue:54 Volume:11 Page:34024-34035
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Natal Carolina M.¹,Fernandes Maria José G.¹,Pinto Nuno F. S.¹,Pereira Renato B.²^ORCID,Vieira Tatiana F.³⁴^ORCID,Rodrigues Ana Rita O.⁵^ORCID,Pereira David M.²^ORCID,Sousa Sérgio F.³⁴^ORCID,Fortes A. Gil¹,Castanheira Elisabete M. S.⁵^ORCID,T. Gonçalves M. Sameiro¹^ORCID

Affiliation:

1. Centre of Chemistry, Department of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal

2. REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

3. Associate Laboratory i4HB – Institute for Health and Bioeconomy, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

4. UCIBIO – Applied Molecular Biosciences Unit, BioSIM – Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

5. Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal

Abstract

Thymol and carvacrol derivatives were synthesised. Two of them proved to be mildly active against Sf9 insect cell line and one has presented selectivity by proving to be less toxic to human cells than the naturally derived starting materials.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA05616F

Reference61 articles.

1. Synthesis and leishmanicidal activity of eugenol derivatives bearing 1,2,3-triazole functionalities

2. Natural products for pest control: an analysis of their role, value and future

3. The development, regulation and use of biopesticides for integrated pest management

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Multifaceted computational profiling of thymol and geraniol against the human proteome for bio-repellent alternatives: Toxicity predictions, degradation analysis, and quantum mechanical approaches;Acta Tropica;2024-10

2. Exploring Chemical Variability in the Essential Oils of the Thymus Genus;Plants;2024-05-15

3. Phytocytogenotoxicity of Esters obtained from Phenols and Phenoxyacetic Acid using the Steglich reaction;2024-04-01

4. Combined in vitro/in silico approaches, molecular dynamics simulations and safety assessment of the multifunctional properties of thymol and carvacrol: A comparative insight;Chemistry & Biodiversity;2024-01-15

5. Synthesis and biological evaluation of several new heterocyclic carvacrol esters;Journal of Molecular Structure;2024-01