A molecular dynamics model for glycosylphosphatidyl-inositol anchors: “flop down” or “lollipop”?-Reference-Cited by-同舟云学术

A molecular dynamics model for glycosylphosphatidyl-inositol anchors: “flop down” or “lollipop”?

Published:2018 Issue:46 Volume:20 Page:29314-29324
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Banerjee Pallavi¹²³⁴,Wehle Marko¹²³⁴,Lipowsky Reinhard¹²³⁴^ORCID,Santer Mark¹²³⁴^ORCID

Affiliation:

1. Department of Theory and Biosystems

2. Max Planck Institute for Colloids and Interfaces

3. 14424 Potsdam

4. Germany

Abstract

Computational model for GPI anchors tested in DMPC and POPC bilayers. The free anchor rarely occurs as an erected “lollipop-like” conformation, it rather “flops down” onto the bilayer surface. Yet an attached protein (here green fluorescent protein) exhibits extensive orientational flexibility due to the phospho-ethanolamine linker.

Funder

Max-Planck-Gesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP04059A

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