Divergolide congeners illuminate alternative reaction channels for ansamycin diversification-Reference-Cited by-同舟云学术

Divergolide congeners illuminate alternative reaction channels for ansamycin diversification

Published:2015 Issue:6 Volume:13 Page:1618-1623
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ding Ling¹²³⁴⁵,Franke Jakob¹²³⁴⁵,Hertweck Christian¹²³⁴⁵

Affiliation:

1. Leibniz Institute for Natural Product Research and Infection Biology

2. HKI

3. Department of Biomolecular Chemistry

4. 07745 Jena

5. Germany

Abstract

Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02244K

Reference36 articles.

1. RifamycinMode of Action, Resistance, and Biosynthesis

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5. Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699

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