New Cy5 photosensitizers for cancer phototherapy: a low singlet–triplet gap provides high quantum yield of singlet oxygen

Author:

Ma He1,Long Saran12,Cao Jianfang3,Xu Feng1,Zhou Panwang4ORCID,Zeng Guang5,Zhou Xiao1,Shi Chao1,Sun Wen12ORCID,Du Jianjun12ORCID,Han Keli6ORCID,Fan Jiangli12ORCID,Peng Xiaojun12ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

2. State Key Laboratory of Fine Chemicals and Shenzhen Research Institute, Dalian University of Technology, Dalian 116024, China

3. School of Chemical Engineering, Dalian University of Technology, Panjin Campus, Panjin 124221, China

4. Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, China

5. State Key Laboratory of Catalysis, Dalian Institute of Chemical and Physics, Chinese Academy of Sciences, Zhongshan Road 457, Dalian 116023, China

6. State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457, Zhongshan Road, Dalian 116023, China

Abstract

The electron-withdrawing group at the meso-position of Thio-Cy5 could dramatically reduce the singlet–triplet energy gap, and speed up the intersystem crossing process.

Funder

National Natural Science Foundation of China

National Natural Science Foundation of China-Liaoning Joint Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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