Mitigating RANKL-induced cholesterol overload in macrophages with β-cyclodextrin-threaded polyrotaxanes suppresses osteoclastogenesis-Reference-Cited by-同舟云学术

Mitigating RANKL-induced cholesterol overload in macrophages with β-cyclodextrin-threaded polyrotaxanes suppresses osteoclastogenesis

Published:2022 Issue:18 Volume:10 Page:5230-5242
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhu Hongfei¹,Tamura Atsushi²^ORCID,Zhang Shunyao²,Terauchi Masahiko¹,Yoda Tetsuya¹,Yui Nobuhiko²^ORCID

Affiliation:

1. Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan

2. Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan

Abstract

Effects of cyclodextrins and polyrotaxanes (PRXs) on osteoclastogenesis were examined. PRXs suppressed RANKL-induced free cholesterol overload and osteoclastogenesis in macrophages.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00833E

Reference52 articles.

1. Osteoclast differentiation and activation

2. Osteoporosis: now and the future

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4. The molecular understanding of osteoclast differentiation

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