Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein-Reference-Cited by-同舟云学术

Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein

Published:2023 Issue:5 Volume:14 Page:858-868
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Wongso Hendris¹²³^ORCID,Ono Maiko⁴,Yamasaki Tomoteru⁵,Kumata Katsushi⁵,Higuchi Makoto⁴,Zhang Ming-Rong⁵^ORCID,Fulham Michael J.⁶^ORCID,Katsifis Andrew⁶^ORCID,Keller Paul A.¹^ORCID

Affiliation:

1. School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia

2. Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, National Research and Innovation Agency, Puspiptek, Banten 15314, Indonesia

3. Research Collaboration Center for Theranostic Radiopharmaceuticals, National Research and Innovation Agency, Sumedang 45363, Indonesia

4. Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan

5. Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan

6. Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia

Abstract

A series of tau ligands was synthesized replacing the photoisomerisable trans-diene bridge of PBB3 with 1,2,3-triazole, amide, and ester moieties. Several ligands were able to visualise Aβ plaques and neurofibrillary tangles in Alzheimer's disease.

Funder

Kementerian Riset dan Teknologi/Badan Riset dan Inovasi Nasional

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00358A

Reference26 articles.

1. Epidemiology, associated burden, and current clinical practice for the diagnosis and management of Alzheimer’s disease in Japan

2. Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease

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4. New approaches for the treatment of Alzheimer’s disease

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