Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1-Reference-Cited by-同舟云学术

Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1

Published:2021 Issue:37 Volume:12 Page:12468-12475
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Liu Qiang¹^ORCID,Knobloch Gunnar²^ORCID,Voorneveld Jim¹,Meeuwenoord Nico J.¹,Overkleeft Herman S.¹^ORCID,van der Marel Gijsbert A.¹^ORCID,Ladurner Andreas G.²³,Filippov Dmitri V.¹^ORCID

Affiliation:

1. Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands

2. Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU Munich, 82152, Planegg-Martinsried, Germany

3. Eisbach Bio GmbH, Am Klopferspitz 19, Planegg-Martinsried, 82152, Germany

Abstract

We report the synthesis of linear ADPr oligomers of defined length up to a pentamer using an improved solid phase method. Binding study with human oncogenic helicase ALC1 shows that ADPr oligomers bind to ALC1 in a length-dependent manner.

Funder

Deutsche Forschungsgemeinschaft

Paul-Ehrlich-Gesellschaft Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02340C

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