Understanding the mechanical link between oriented cell division and cerebellar morphogenesis
Author:
Affiliation:
1. Department of Civil and Environmental Engineering
2. Stanford University
3. Stanford
4. USA
5. Institute for Computational Engineering & Sciences
6. Department of Mechanical Engineering
Abstract
Three-dimensional multiscale modeling shows that oriented cell division leads to a mechanical instability that can initiate cerebellar foliation.
Funder
National Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
Condensed Matter Physics,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/SM/C8SM02231C
Reference46 articles.
1. Consensus Paper: Cerebellar Development
2. Morphology, Molecular Codes, and Circuitry Produce the Three-Dimensional Complexity of the Cerebellum
3. Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
4. The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation
5. Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers
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