Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension

Author:

Fejes Rebeka12ORCID,Lutnik Martin3ORCID,Weisshaar Stefan3,Pilat Nina4ORCID,Wagner Karl-Heinz1,Stüger Hans-Peter5,Peake Jonathan M.6,Woodman Richard J.7,Croft Kevin D.8ORCID,Bondonno Catherine P.9ORCID,Hodgson Jonathan M.9,Wolzt Michael3,Neubauer Oliver110ORCID

Affiliation:

1. Department of Nutritional Sciences, Research Platform Active Ageing, University of Vienna, Vienna, Austria

2. Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, Austria

3. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

4. Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria

5. Division Integrative Risk Assessment, Data and Statistics, Austrian Agency for Health and Food Safety, Vienna, Austria

6. School of Biomedical Sciences, Queensland University of Technology, Queensland, Australia

7. Flinders Centre for Epidemiology and Biostatistics, Flinders University, Adelaide, South Australia, Australia

8. Medical School, University of Western Australia, Royal Perth Hospital Unit, Perth, Western Australia, Australia

9. Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Royal Perth Hospital Research Foundation, Edith Cowan University, Joondalup, Western Australia, Australia

10. Centre for Health Sciences and Medicine, University for Continuing Education Krems, Krems, Austria

Abstract

In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate via NO translate into improved vascular function and blood pressure-lowering in middle-aged and older men and women with treated hypertension.

Funder

Austrian Science Fund

Publisher

Royal Society of Chemistry (RSC)

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