An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization-Reference-Cited by-同舟云学术

An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization

Published:2021 Issue:18 Volume:50 Page:6071-6075
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Štarha Pavel¹²³⁴⁵^ORCID,Drahoš Bohuslav¹²³⁴⁵^ORCID,Herchel Radovan¹²³⁴⁵^ORCID

Affiliation:

1. Department of Inorganic Chemistry

2. Faculty of Science

3. Palacký University in Olomouc

4. 771 46 Olomouc

5. Czech Republic

Abstract

Complex cis-[PtI₂(NH₃)(pic)] (pic = 2-methylpyridine), an iodido analogue of picoplatin, released the N-donor pic ligand in solution and isomerized, which complicates its subsequent testing for cytotoxicity.

Funder

Univerzita Palackého v Olomouci

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT00740H

Reference34 articles.

1. The resurgence of platinum-based cancer chemotherapy

2. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

3. In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473

4. ZD0473 treatment in lung cancer: an overview of the clinical trial results

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A novel Pt2+ complex containing 1,4-benzodioxan-6-amine: Stability, DNA binding, and antitumor effects against human breast cancer cells;Chemistry of Inorganic Materials;2024-08

2. Platinum(IV) and platinum(II) anticancer complexes with biologically active releasable ligands;Coordination Chemistry Reviews;2024-02

3. Metal Complexes in Cancer Treatment: Journey So Far;Chemistry & Biodiversity;2023-03-13

4. New Pt(II) diiodido complexes containing bidentate 1,3,4-thiadiazole-based ligands: Synthesis, characterization, cytotoxicity;Inorganica Chimica Acta;2022-06

5. Novel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action;Bioinorganic Chemistry and Applications;2022-03-02