Synthesis of 4-(trichloromethyl)pyrido[2′,1′:3,4]pyrazino[2,1-<i>b</i>]quinazolinones through a cyclized dearomatization and trichloromethylation cascade strategy-Reference-Cited by-同舟云学术

Synthesis of 4-(trichloromethyl)pyrido[2′,1′:3,4]pyrazino[2,1-b]quinazolinones through a cyclized dearomatization and trichloromethylation cascade strategy

Published:2024 Issue:7 Volume:22 Page:1386-1390
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhang Xu¹,Wei Meng-Yan¹,Su Jun-Cheng¹^ORCID,Liang Cui¹,Pan Cheng-Xue¹^ORCID,Su Gui-Fa¹^ORCID,Mo Dong-Liang¹^ORCID

Affiliation:

1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China

Abstract

An intramolecular 6-endo-dig cyclization and trichloromethylation of N3-alkynyl-2-pyridinyl-tethered quinazolinones in chloroform was developed for the synthesis of various 4-trichloromethylated pyrido-fused quinazolinones in moderate to good yields with high regioselectivity.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Zhuang Autonomous Region

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D3OB02084C

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4. A Tetrachloro Polyketide Hexahydro-1H-isoindolone, Muironolide A, from the Marine Sponge Phorbas sp. Natural Products at the Nanomole Scale

5. ATRA-like alkylation–peroxidation of alkenes with trichloromethyl derivatives by the combination of tBuOOH and NEt3