Differential interactions of imatinib mesylate with the membrane skeletal protein spectrin and hemoglobin
Author:
Affiliation:
1. Crystallography & Molecular Biology Division
2. Saha Institute of Nuclear Physics
3. HBNI
4. Kolkata 700064
5. India
6. Biophysics, Molecular Biology and Bioinformatics
7. University of Calcutta
8. Kolkata 700009
9. Chemistry Department
Abstract
The anti-leukaemia drug imatinib has been shown to bind to spectrin, and to hemoglobin in its oxy-form with binding dissociation constants of 48 μM and 63 μM at 25 °C respectively.
Funder
Department of Atomic Energy, Government of India
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA27276A
Reference51 articles.
1. Oncogenic Fusion Tyrosine Kinases as Molecular Targets for Anti-Cancer Therapy
2. Imatinib: a selective tyrosine kinase inhibitor
3. Gastrointestinal stromal tumors (GIST): C-kit mutations, CD117 expression, differential diagnosis and targeted cancer therapy with imatinib
4. Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia
5. Role of alpha1 Acid Glycoprotein in the In Vivo Resistance of Human BCR-ABL+ Leukemic Cells to the Abl Inhibitor STI571
Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Spectrin: an alternate target for cytoskeletal drugs;Journal of Biomolecular Structure and Dynamics;2022-08-22
2. Effect of organo-selenium anticancer drugs on nitrite induced methemoglobinemia: A spectroscopic study;Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy;2021-01
3. Caffeine and catechin towards prevention of drug induced oxidation of hemoglobin: A spectroscopic study;Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy;2020-05
4. Exploring the binding of two potent anticancer drugs bosutinib and imatinib mesylate with bovine serum albumin: spectroscopic and molecular dynamic simulation studies;Analytical and Bioanalytical Chemistry;2017-08-29
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3