A polysaccharide extracted from alfalfa activates splenic B cells by TLR4 and acts primarily via the MAPK/p38 pathway

Author:

Xie Yuhuai12345,Wang Lixue12345,Sun Hua675,Shang Qinghui89105,Wang Yuxi1112131415,Zhang Guiguo12345,Yang Weiren12345ORCID,Jiang Shuzhen12345

Affiliation:

1. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention

2. College of Animal Science and Veterinary Medicine

3. Shandong Agricultural University

4. Tai'an

5. PR China

6. Qilu University of Technology (Shandong Academy of Sciences)

7. Jinan

8. Department of Animal Science and Technology

9. China Agricultural University

10. Beijing

11. Lethbridge Research Centre

12. Agriculture and Agri-Food C

13. Lethbridge

14. anada

15. Canada

Abstract

Alfalfa polysaccharide (APS) activates the immune functions of splenic B cells by TLR4, acting through the MAPK and NF-κB signaling pathways, and potently activates the p38 pathway.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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