Xanthine oxidase–product complexes probe the importance of substrate/product orientation along the reaction coordinate

Author:

Yang Jing1234,Dong Chao1234,Kirk Martin L.1234ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology

2. The University of New Mexico

3. Albuquerque

4. USA

Abstract

Resonance Raman spectroscopy has been used to probe substrate orientation and hydrogen bonding interactions in a xanthine oxidase catalytic intermediate.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference49 articles.

1. The Mononuclear Molybdenum Enzymes

2. Molybdenum enzymes in higher organisms

3. Electronic structure contributions to reactivity in xanthine oxidase family enzymes

4. M. L. Kirk and B.Stein, The Molybdenum Enzymes, in Comprehensive Inorganic Chemistry II, Editors-in-Chief: ed. R. Jan and P. Kenneth, Elsevier, Amsterdam, 2nd edn, 2013, pp. 263–293

5. Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

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