Serum proteins on nanoparticles: early stages of the “protein corona”-Reference-Cited by-同舟云学术

Serum proteins on nanoparticles: early stages of the “protein corona”

Published:2021 Issue:48 Volume:13 Page:20550-20563
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

McColman Sarah¹²³^ORCID,Li Rui³,Osman Selena¹²,Bishop Amanda³,Wilkie Kathleen P.⁴^ORCID,Cramb David T.¹²³^ORCID

Affiliation:

1. Department of Chemistry and Biology, Faculty of Science, Ryerson University, 350 Victoria Street, Toronto ON M5B 2 K3, Canada

2. Institute for Biomedical Engineering, Science, and Technology (iBEST), Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Toronto ON M5B 1 T8, Canada

3. Department of Chemistry, Faculty of Science, University of Calgary, 2500 University Dr NW, Calgary, AB T2N 1N4, Canada

4. Department of Mathematics, Faculty of Science, Ryerson University, 350 Victoria Street, Toronto ON M5B 2 K3, Canada

Abstract

Nanoparticles are studied with respect to serum albumin binding using a direct and quantitative approach. We find that protein binding saturation occurs at sub-monolayer surface coverage and attribute binding to surface chemistry heterogeneity.

Funder

University of Calgary

Ryerson University

Alberta Innovates - Technology Futures

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR06137B

Reference50 articles.