Chiral phosphoric acid-catalyzed chemo and enantioselective 1,2-addition of isatin-derived β,γ-unsaturated α-ketoesters with 4-aminoindoles at the C7 position-Reference-Cited by-同舟云学术

Chiral phosphoric acid-catalyzed chemo and enantioselective 1,2-addition of isatin-derived β,γ-unsaturated α-ketoesters with 4-aminoindoles at the C7 position

Published:2023 Issue:3 Volume:10 Page:718-723
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhao Yunlong¹²,Xiao Rou¹,Fang Weibin¹,Zhao Junling¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, P. R. China

2. Hebei Key Laboratory of Organic Functional Molecules, College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050024, P. R. China

Abstract

The chemo and enantioselective 1,2-addition of isatin-derived β,γ-unsaturated α-ketoesters with indoles at the C7 position was described. Some of the products showed high in vitro cytotoxicity towards several human cancer cell lines.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D2QO01763F

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