Transition-metal-free chemoselective catalytic hydrosilylation of tertiary amides to hemiaminals by Me<sub>2</sub>SiH<sub>2</sub>generated from controllable disproportionation of 1,1,3,3-tetramethyldisiloxane-Reference-Cited by-同舟云学术

Transition-metal-free chemoselective catalytic hydrosilylation of tertiary amides to hemiaminals by Me₂SiH₂generated from controllable disproportionation of 1,1,3,3-tetramethyldisiloxane

Published:2023 Issue:5 Volume:10 Page:1198-1205
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Wu Xiaoyu¹,Wang Yue¹,Yang Liqun¹,Xie Xiaomin¹,Zhang Zhaoguo¹^ORCID

Affiliation:

1. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

Abstract

We present a KOtBu-catalyzed hydrosilylation for the chemoselective reduction of various tertiary amides to hemiaminals. Mechanistic investigations reveal a controllable disproportionation of TMDS to generate the distinctive reductant Me2SiH2.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D2QO01766K

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