Photo-induced telomeric DNA damage in human cancer cells-Reference-Cited by-同舟云学术

Photo-induced telomeric DNA damage in human cancer cells

Published:2022 Issue:12 Volume:3 Page:1375-1379
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Weynand Justin¹²^ORCID,Episkopou Harikleia³,Le Berre Gabriel³,Gillard Martin¹^ORCID,Dejeu Jérôme²^ORCID,Decottignies Anabelle³,Defrancq Eric²^ORCID,Elias Benjamin¹^ORCID

Affiliation:

1. Université catholique de Louvain (UCLouvain), Institut de la Matière Condensée et des Nanosciences (IMCN), Molecular Chemistry, Materials and Catalysis (MOST), Place Louis Pasteur 1, bte L4.01.02, B-1348 Louvain-la-Neuve, Belgium

2. Université Grenoble-Alpes (UGA), Département de Chimie Moléculaire, UMR CNRS 5250, CS 40700, 38058 Grenoble, France

3. Université catholique de Louvain (UCLouvain), Genetic and Epigenetic Alterations of Genomes, de Duve Institute, Avenue Hippocrate 75, 1200 Brussels, Belgium

Abstract

Novel dinuclear ruthenium(ii) complexes were designed to target and to photo-react with G-quadruplex telomeric DNA. Thanks to a microscopic-based telomere dysfunction assay, we brought the first evidence of G-driven telomeric DNA photo-lesions in cellulo.

Funder

Agence Nationale de la Recherche

Fonds De La Recherche Scientifique - FNRS

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00192F

Reference38 articles.

1. DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

2. Single-molecule visualization of DNA G-quadruplex formation in live cells