Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors-Reference-Cited by-同舟云学术

Access to 3-spiroindolizines containing an isoindole ring through intra-molecular arylation of spiro-N-acyliminium species: a new family of potent farnesyltransferase inhibitors

Published:2019 Issue:10 Volume:17 Page:2798-2808
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Pesquet Anthony¹²³⁴⁵,Marzag Hamid¹²³⁴⁵,Knorr Michael⁶⁷⁸⁹^ORCID,Strohmann Carsten¹⁰¹¹¹²¹³,Lawson Ata Martin¹²³⁴⁵^ORCID,Ghinet Alina¹⁴¹⁵¹⁶¹⁷¹⁸^ORCID,Dubois Joëlle¹⁹²⁰³²¹²²^ORCID,Amaury Farce²³²⁴²⁵²⁶²⁷,Daïch Adam¹²³⁴⁵^ORCID,Othman Mohamed¹²³⁴⁵

Affiliation:

1. Normandie Univ

2. UNILEHAVRE

3. CNRS

4. URCOM

5. 76600 Le Havre

6. Institut UTINAM-UMR CNRS 6213

7. Université Bourgogne Franche-Comté

8. 25030 Besançon

9. France

10. Anorganische Chemie

11. Technische Universität Dortmund

12. 44227 Dortmund

13. Germany

14. Faculty of Chemistry

15. ‘Al. I. Cuza’ University of Iasi

16. Iasi

17. Romania

18. Laboratoire de Pharmacochimie

19. Institut de Chimie des Substances Naturelles

20. UPR2301

21. Centre de Recherche de Gif

22. F-91198 Gif-sur-Yvette Cedex

23. Univ. Lille

24. Inserm

25. CHU Lille

26. U995-LIRIC-Lille Inflammation Research International Center

27. F-59000 Lille

Abstract

Based on N-acyliminium species, two efficient and rapid approaches to diversify spirocyclic systems connected by two different carbon centers to the isoindole ring have been developed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02612B

Reference66 articles.

1. C. H. Heathcock , S. L.Graham , M. C.Pirrung , F.Plavac and C. T.White , Spirocyclic Systems , in The Total Synthesis of Natural Products , ed. J. A. Simon , John Wiley and Sons , New York , 1983 , vol. 5 , pp. 264

2. Stereocontrolled synthesis of spirocyclics

3. The chemistry of isatins: a review from 1975 to 1999

4. Paraherquamides, Brevianamides, and Asperparalines: Laboratory Synthesis and Biosynthesis. An Interim Report

5. Recent advances in spirocyclization of indole derivatives

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Downregulation of HSP27 by isoindole-derived pyrrolidines suppressing multidrug resistance (MDR) and inducing apoptosis in MCF-7 and DLD-1 cell lines;Indian Journal of Experimental Biology;2024-04-27

2. Magnesium oxide nanoparticles administered orally promote degenerative changes and dysfunctioning in the brain;Indian Journal of Experimental Biology;2024-04-27

3. Substrate Controlled [3+3] Relay Catalytic Cyclization of α‐(3‐Isoindolinonyl) Propargylic Alcohols with 5‐Aminoisoxazoles;Asian Journal of Organic Chemistry;2024-04-11

4. Enantioselective intramolecular tandem cyclization of o-alkynylbenzamides: generation of enantioenriched CF₃-containing spiro-isoindolinone-indoles;Organic Chemistry Frontiers;2024

5. FTase inhibitors and cancer: prospects for use in targeted therapies;Medicinal Chemistry Research;2023-12-09