Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein-Reference-Cited by-同舟云学术

Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein

Published:2020 Issue:39 Volume:10 Page:23466-23483
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Adewumi Adeniyi T.¹²³⁴⁵^ORCID,Soremekun Opeyemi S.¹²³⁴⁵^ORCID,Ajadi Mary B.⁶⁷⁸³⁹^ORCID,Soliman Mahmoud E. S.¹²³⁴⁵^ORCID

Affiliation:

1. Molecular Bio-computation and Drug Design Laboratory

2. School of Health Sciences

3. University of KwaZulu-Natal

4. Durban 4001

5. South Africa

6. Department of Medical Biochemistry

7. School of Laboratory Medicine and Medical Sciences

8. College of Health Sciences

9. Durban 4000

Abstract

Graphical superimposed snapshots of the Thompson novel loop (yellow) of menG protein: apo (A) and bound (B) systems. The loop switches between open and closed conformations; critical for therapeutic activity.

Funder

Inyuvesi Yakwazulu-Natali

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03206A

Reference69 articles.

1. Estimating the future burden of multidrug-resistant and extensively drug-resistant tuberculosis in India, the Philippines, Russia, and South Africa: a mathematical modelling study

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3. High Prevalence of Bedaquiline Resistance in Treatment-Naive Tuberculosis Patients and Verapamil Effectiveness

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