Microwave-assisted copper(<scp>i</scp>) catalyzed A3 cascade coupling of imidazo[1,2-a]pyridines via C–H bond functionalization as selective COX-2 inhibitors and antioxidants, and in silico studies-Reference-Cited by-同舟云学术

Microwave-assisted copper(i) catalyzed A³ cascade coupling of imidazo[1,2-a]pyridines via C–H bond functionalization as selective COX-2 inhibitors and antioxidants, and in silico studies

Published:2023 Issue:19 Volume:47 Page:9401-9413
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Nesaragi Aravind R.¹²,Kamble Ravindra R.¹^ORCID,Hoolageri Swati R.¹^ORCID,Dixit Shruti³^ORCID,Joshi Shrinivas D.⁴,Vootla Shyamkumar³^ORCID,Kumbar Vijay M.⁵

Affiliation:

1. Department of Studies in Chemistry, Karnatak University, Dharwad-580003, India

2. Centre for Nano and Material Sciences, Jain (Deemed-to-be University), Jain Global Campus, Kanakapura, Bangalore-562112, Karnataka, India

3. Department of Biotechnology and Microbiology, Karnatak University, Dharwad-580003, India

4. Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, S.E.T.'s College of Pharmacy, Dharwad-580002, India

5. Central Research Laboratory, Maratha Mandal's NGH Institute of Dental Sciences and Research Centre, Belagavi-590010, India

Abstract

A proficient copper(i) catalyzed one pot synthetic protocol has been established to synthesize medicinally essential substituted imidazo[1,2-a]pyridines via C–H bond amination followed by acetylene incorporation under microwave irradiation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ00524K

Reference36 articles.

1. Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies

2. Molecular Dynamics Simulations of Arachidonic Acid Complexes with COX-1 and COX-2: Insights into Equilibrium Behavior

3. Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs

4. Gastroscopic evaluation of anti-inflammatory agents

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