Synthesis of cis-stilbene-based 1,2,4-triazole/1,3,4-oxadiazole conjugates as potential cytotoxic and tubulin polymerization inhibitors

Author:

John Stephy Elza1,Sharma Anamika2,Gulati Shivani1,Bora Darshana1,Shankaraiah Nagula1ORCID

Affiliation:

1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India

2. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India

Abstract

The currently designed molecules demonstrated potential anti-cancer activity by the induction of apoptosis and tubulin polymerization inhibition.

Funder

Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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