Rapid building block-economic synthesis of long, multi-<i>O</i>-GalNAcylated MUC5AC tandem repeat peptides-Reference-Cited by-同舟云学术

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Rapid building block-economic synthesis of long, multi-O-GalNAcylated MUC5AC tandem repeat peptides

Published:2024 Issue:4 Volume:15 Page:1297-1305
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Galashov Arseniy¹^ORCID,Kazakova Ekaterina¹,Stieger Christian E.²,Hackenberger Christian P. R.¹²^ORCID,Seitz Oliver¹^ORCID

Affiliation:

1. Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489, Berlin, Germany

2. Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125, Berlin, Germany

Abstract

New methods allow the very smooth synthesis of highly pure MUC5AC glycopeptides containing 20 GalNAc units on 10 tandem repeats within a week.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05006H

Reference67 articles.

1. Mucins and Their Role in Shaping the Functions of Mucus Barriers

2. Mucins: A biologically relevant glycan barrier in mucosal protection

3. Engineering mucus to study and influence the microbiome

4. Tandem repeats structure of gel-forming mucin domains could be revealed by SMRT sequencing data

5. Glycosylation in health and disease

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