Conformationally constrained nucleoside phosphonic acids – potent inhibitors of human mitochondrial and cytosolic 5′(3′)-nucleotidases-Reference-Cited by-同舟云学术

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Conformationally constrained nucleoside phosphonic acids – potent inhibitors of human mitochondrial and cytosolic 5′(3′)-nucleotidases

Published:2014 Issue:40 Volume:12 Page:7971-7982
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Šimák Ondřej¹²³,Pachl Petr¹²³⁴⁵,Fábry Milan⁴⁵⁶,Buděšínský Miloš¹²³,Jandušík Tomáš¹²³⁷⁸,Hnízda Aleš¹²³,Skleničková Radka¹²³,Petrová Magdalena¹²³,Veverka Václav¹²³,Řezáčová Pavlína¹²³⁴⁵,Brynda Jiří¹²³⁴⁵,Rosenberg Ivan¹²³

Affiliation:

1. Institute of Organic Chemistry and Biochemistry

2. Academy of Sciences of the Czech Republic

3. 166 10 Prague 6, Czech Republic

4. Institute of Molecular Genetics

5. of Sciences of the Czech Republic

6. 14220 Prague 4, Czech Republic

7. Department of Chemistry of Natural Compounds

8. Institute of Chemical Technology

Abstract

Conformationally constrained nucleoside phosphonic acids – potent inhibitors of human mitochondrial and cytosolic 5′(3′)-deoxynucleotidases.

Funder

Czech Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01332H

Reference53 articles.

1. The 5′-nucleotidases as regulators of nucleotide and drug metabolism

2. Interrelations between substrate cycles and de novo synthesis of pyrimidine deoxyribonucleoside triphosphates in 3T6 cells.

3. Is the Expression of Deoxynucleoside Kinases and 5'-nucleotidases in Animal Tissues Related to the Biological Effects of Nucleoside Analogs?

4. Molecular characterization of six unrelated Italian patients affected by pyrimidine 5′-nucleotidase deficiency

5. Crystal Structure of Human Cytosolic 5′-Nucleotidase II

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1. Efficient microwave-assisted selective alkaline hydrolysis of diversely substituted phosphonate esters;Green Chemistry;2022

2. Synthesis of phosphonate derivatives of 2′-deoxy-2′-fluorotetradialdose d-nucleosides and tetradialdose d-nucleosides;Tetrahedron;2021-04

3. Structure-Based Optimization of Bisphosphonate Nucleoside Inhibitors of Human 5′(3′)-deoxyribonucleotidases;European Journal of Organic Chemistry;2018-07-26

4. 4-Toluenesulfonyloxymethyl-(H)-phosphinate: A Reagent for the Introduction of O- and S-Methyl-(H)-phosphinate Moieties;Organic Letters;2016-05-13

5. Structure-based design of a bisphosphonate 5′(3′)-deoxyribonucleotidase inhibitor;MedChemComm;2015

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