Multimodal imaging of drug and excipients in rat lungs following an inhaled administration of controlled-release drug laden PLGA microparticles-Reference-Cited by-同舟云学术

Multimodal imaging of drug and excipients in rat lungs following an inhaled administration of controlled-release drug laden PLGA microparticles

Published:2021 Issue:10 Volume:146 Page:3378-3390
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Robinson Eve¹²³,Giffen Paul¹²³,Hassall Dave¹²³,Ball Doug¹²³,Reid Heather¹²³,Coe Diane¹²³,Teague Simon¹²³,Terry Rebecca¹²³,Earl Meredith⁴⁵⁶,Marchand Joseph⁴⁵⁶,Farrer Brian⁴⁵⁶,Havelund Rasmus⁷⁸³,Gilmore Ian S.⁷⁸³,Marshall Peter S.¹²³^ORCID

Affiliation:

1. GlaxoSmithKline

2. Stevenage

3. UK

4. Liquidia Technologies

5. Morrisville

6. USA

7. National Physical Laboratory

8. Teddington

Abstract

The use of multimodal imaging techniques, in particular MALDI MS Imaging, TOF-SIMS and histopathology, to spatially map the distribution of drug and excipients (microparticles) in rat lung sections following inhaled administration is demonstrated.

Funder

Department for Business, Energy and Industrial Strategy, UK Government

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/AN/D0AN02333G

Reference44 articles.

1. Delivering drugs by the transdermal route: review and comment

2. Multimodal imaging approach to examine biodistribution kinetics of Cabotegravir (GSK1265744) long acting parenteral formulation in rat

3. Prediction of Drug Residence Times in Regions of the Human Respiratory Tract Following Aerosol Inhalation

4. Recent Advances in Controlled Release Pulmonary Therapy

5. Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions

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