Uncoupling of an ammonia channel as a mechanism of allosteric inhibition in anthranilate synthase of Serratia marcescens: dynamic and graph theoretical analysis-Reference-Cited by-同舟云学术

Uncoupling of an ammonia channel as a mechanism of allosteric inhibition in anthranilate synthase of Serratia marcescens: dynamic and graph theoretical analysis

Published:2017 Issue:1 Volume:13 Page:142-155
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Srivastava Ashutosh¹²³⁴⁵,Sinha Somdatta¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Protein Science

2. Design

3. Engineering (CPSDE)

4. Department of Biological Sciences

5. Indian Institute of Science Education Research Mohali

Abstract

Network modeling and molecular dynamic studies reveal the perturbation in communication pathways as a mechanism of allosteric inhibition in anthranilate synthase.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MB/C6MB00646A

Reference49 articles.

1. A Metabolic Node in Action: Chorismate-Utilizing Enzymes in Microorganisms

2. Purification and characterization of anthranilate synthase component I (TrpE) from Mycobacterium tuberculosis H37Rv

3. Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

4. Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

5. Molecular studies on enzymes in chorismate metabolism and the enterobactin biosynthetic pathway

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