Complete characterization of RNA biomarker fingerprints using a multi-modal ATR-FTIR and SERS approach for label-free early breast cancer diagnosis-Reference-Cited by-同舟云学术

Complete characterization of RNA biomarker fingerprints using a multi-modal ATR-FTIR and SERS approach for label-free early breast cancer diagnosis

Published:2024 Issue:5 Volume:14 Page:3599-3610
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhang Shuyan¹^ORCID,Wu Steve Qing Yang¹,Hum Melissa²,Perumal Jayakumar¹,Tan Ern Yu³⁴,Lee Ann Siew Gek²⁵⁶,Teng Jinghua¹^ORCID,Dinish U. S.¹^ORCID,Olivo Malini¹

Affiliation:

1. Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore, 138634, Republic of Singapore

2. Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore (NCCS), 30 Hospital Boulevard, Singapore, 168583, Republic of Singapore

3. Breast & Endocrine Surgery, Tan Tock Seng Hospital (TTSH), 11 Jln Tan Tock Seng, Singapore, 308433, Republic of Singapore

4. Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Republic of Singapore

5. SingHealth Duke-NUS Oncology Academic Clinical Programme (ONCO ACP), Duke-NUS Medical School, Singapore 169857, Republic of Singapore

6. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Republic of Singapore

Abstract

With the multi-modal approach combining ATR-FTIR and SERS, we achieved an extended spectral range for molecular fingerprint detection of RNA biomarkers. Machine learning results shows 91.6% blind test accuracy for label-free breast cancer diagnosis.

Funder

Agency for Science, Technology and Research

Biomedical Research Council

National Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA05723B

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